The registrant/filer should follow the requirements of the Technical Guidelines for Cosmetics Safety Assessment to determine potential health hazard effects of ingredients based on factors such as product usage, exposure routes, and actual exposure levels.
Additionally, depending on the physicochemical properties of the ingredient, quantitative structure-activity relationships, toxicological data, usage history, clinical studies, epidemiological investigations, and toxicity data of similar compounds, certain toxicological endpoints may be added or exempted from assessment. For example, if sufficient evidence confirms that a certain ingredient has a history of safe consumption, the assessment of systemic toxicity as a toxicological endpoint may be exempted.