According to the Cosmetics Supervision and Administration Regulations, applicants for the registration or notification of new cosmetic ingredients are required to submit safety assessment data. For new ingredients that have a well-established history of safe use in cosmetics, certain toxicological study requirements may be waived.
To implement the Provisions on Supporting Innovation in Cosmetic Ingredients issued by the National Medical Products Administration (NMPA) and to enhance the utilization of existing data, the National Institutes for Food and Drug Control (NIFDC) organized the development of the Guideline for the Study and Determination of the Safety Use History of New Cosmetic Ingredients (Trial) (hereinafter referred to as the "Guideline"). This Guideline provides technical guidance on the collection, evaluation, and application of historical safety use data in the safety assessment of new cosmetic ingredients.