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China
Ministry Rules
To Be Enforced
No.51 of 2026
Determination of 1-hydroxyethyl-4,5-diaminopyrazole sulfate and other 10 kinds of ingredients in cosmetics
Update Date: Jun 2, 2026
Latest Published
May 29, 2026
Implemented
Mar 1, 2027
Abolished
Industry:
Cosmetic
Region:
Asia
China
Issuing Authority:
State Drug Administration of the People's Republic of China
Main Content:
This method specifies the determination of 1-hydroxyethyl-4,5-diaminopyrazole sulfate and other 10 ingredients in cosmetics by high-performance liquid chromatography (HPLC). This method is applicable to the determination of 1-hydroxyethyl-4,5-diaminopyrazole sulfate and other 10 ingredients in hair dye cosmetics. Cosmetic ingredients may exist in various forms, such as sulfates, hydrochlorides, etc. When multiple forms coexist, they shall be uniformly calculated in one form.
The 11 ingredients covered by this method include: 1-hydroxyethyl-4,5-diaminopyrazole sulfate, hydroxyethyl-p-phenylenediamine sulfate, tetraaminopyrimidine sulfate, 1,3-bis-(2,4-diaminophenoxy)propane hydrochloride, HC Red No. 3, Disperse Black 9, 2-amino-6-chloro-4-nitrophenol, Basic Red 76 (CI 12245), hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride, 2,6-dimethoxy-3,5-pyridinediamine hydrochloride, and 6-methoxy-2-methylamino-3-aminopyridine hydrochloride (HC Blue No. 7).
Operation:
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